Adipose Tissue Development

From Animal Models to Clinical Conditions
3rd ESPE Advanced Seminar in Developmental Endocrinology, Paris, March 2009

Editor(s): Levy-Marchal, C. (Paris)
Pénicaud, L. (Dijon)

Early Determinants of Obesity

Ong K.K.

Author affiliations

MRC Epidemiology Unit, Cambridge, UK

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Levy-Marchal C, Pénicaud L (eds): Adipose Tissue Development: From Animal Models to Clinical Conditions. Endocr Dev. Basel, Karger, 2010, vol 19, pp 53–61

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: June 15, 2010
Cover Date: 2010

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9450-9 (Print)
eISBN: 978-3-8055-9451-6 (Online)


High rates of overweight and obesity even in very young children argue the case for strategies to prevent overweight from very young ages. Historical studies, prospective birth cohorts, and more recently genetic studies all indicate that the rapid weight gain trajectory to later obesity starts in the first months of life, even from birth. Early puberty and age at menarche are consequences of rapid infant weight gain and childhood overweight, and in turn these adolescent traits are predictive for obesity, diabetes, hypertension and cardiovascular disease events in later life. Understanding of the nutritional, parental and wider determinants of rapid infant weight gain are informing the development of obesity prevention strategies starting in early life. Such strategies could be further refined by future studies that address the specific regulation of infant adiposity, and also by studies that explore whether these life-course trajectories are modifiable during adolescence.

© 2010 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: June 15, 2010
Cover Date: 2010

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9450-9 (Print)
eISBN: 978-3-8055-9451-6 (Online)

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